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INTRAOSSEOUS MYOFIBROMA OF THE MANDIBLE IN A 7-YEAR-OLD PATIENT: A CASE
REPORT
NMRR-20-1630-53154S1R0

Meshala BS, Navasheilla RR, Bahruddin S, Zuraiza MZ

Introduction: Myofibroma is a benign fibrous tumour that occurs predominantly in the
head and neck region followed by the trunk and extremities. However, cases occurring in
the oral cavity are rare, presenting with a variable clinical appearances and wide
differential diagnosis. Case report: A 7-year-old girl who was referred to the Department
of Paediatric Dentistry, Tengku Ampuan Rahimah Hospital with a progressively enlarging
painless swelling on the left posterior region of the mandible over the past 3 months. The
swelling was associated with ulceration and displaced lower left first permanent molar.
Radiographic investigations reported well-defined radiolucency at molar area, alveolar
expansion and bone resorption of the left posterior alveolar ridge of the mandible.
Complete surgical excision of the lesion was performed under general anaesthesia.
Histopathological examination revealed proliferation of spindle shaped cells with biphasic
growth pattern. Immunohistochemical staining showed strong positivity with vimentin and
smooth muscle actin whilst negative for desmin, S-100 and CD34 establishing the diagnosis
of myofibroma. Conclusion: Although rare, myofibroma should be considered as a
differential diagnosis for solitary firm swelling in the oral cavity. Histopathological
examination together with immunohistochemical analysis is essential for an accurate
diagnosis and treatment.

Keywords: myofibroma, spindle cell, biphasic growth

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Published in the Malaysian Journal of Paediatrics and Child Health (MJPCH) MJPCH Vol. 27 on 1 June 2021
Dr Meshala Bala Sundram
Dr Navasheilla Retna Retnasingam
Dr Bahruddin Saripudin
Department of Paediatric Dentistry
Tengku Ampuan Rahimah Hospital
Selangor Malaysia

Dr Zuraiza Mohamad Zaini
Department of Oral and Maxillofacial Clinical Sciences
Faculty Of Dentistry
University Malaya Malaysia

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