Page 117 - FINAL COMPENDIUM 2020-2021 27.2.2022

CLINICO-PATHOLOGICAL STUDY OF MALIGNANT ODONTOGENIC TUMOURS FROM A
NATIONAL REFERRAL CENTRE

Sathasivam HP, Saw CL, Lau SH

Introduction: Malignant odontogenic tumours are extremely rare tumours occurring
within the jaws. Objective: To determine the demographic and clinico-pathological
features of malignant odontogenic tumours amongst a multi-ethnic Asian population.
Materials and methods: This was a retrospective cross-sectional study of malignant
odontogenic tumours diagnosed at the Institute for Medical Research, Malaysia, from
2009 to 2019. All cases were independently reviewed and reclassified following the
criteria set out in the latest edition of the World Health Organization 2017 reference text.
Demographic and clinico-pathological data were recorded for each case. Results: Twenty-
four cases of malignant odontogenic tumours were identified. The patients’ age ranged
from 16 to 79 years with the mean age at diagnosis being 50.8 years (SD = 16.18). There
was a male predominance (66.7%) in this cohort of patients. The ethnic distribution
appeared to reflect the Malaysian population with most cases seen amongst the Malay
ethnic group (66.7%). Ameloblastic carcinoma was the most frequently diagnosed
malignant odontogenic tumour (45.8%) and was also predominantly seen in males
(90.9%). All patients with clear cell odontogenic carcinoma were females. There was no
obvious sex predilection in primary odontogenic carcinoma not otherwise specified (NOS).
The mandible (79.2%) was more frequently involved compared to the maxilla. Conclusion:
Diagnosis and management of malignant odontogenic tumours are challenging due to the
rarity of these tumours. Our study has elucidated the clinico-pathological features of
malignant odontogenic tumours seen in a multi-ethnic Asian population.

Published in BMC Oral Health volume 21, Article number: 129 (2021)

Dr Hans P Sathasivam
Institute for Medical Research
National Institutes of Health
Ministry of Health
Malaysia

Dr Saw Chee Lynn
Penang Health Services
Ministry of Health Malaysia
Malaysia

Dr Lau Shin Hin
Institute for Medical Research
National Institutes of Health
Ministry of Health
Malaysia

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