Page 111 - FINAL COMPENDIUM 2020-2021 27.2.2022

EOSINOPHILIC ULCER OF THE ORAL MUCOSA IN CHILDREN

Nurhidayah MN, Aminah M, Mimi Syazleen AR, Sathasivam HP

Introduction: Eosinophilic ulcer (EU) of the oral mucosa is a rare self-limiting oral
condition. It is characterized by painful solitary ulcer, yellow fibrinous base with elevated
and indurated borders. These features may resemble malignancies, traumatic ulcerations,
deep fungal infections, tuberculosis or primary syphilis. The proposed pathogenesis is the
ingression of microorganisms, toxins or foreign protein into the connective tissue through
a traumatized site thus inducing a severe inflammatory response from an exaggerated
mast cell-eosinophil reaction. Case report: A healthy 10 years old boy presented with a
painful ulcerated lump on the lower left buccal mucosa for two weeks duration. Clinical
examination showed an exophytic mass with ulceration present in the middle of the lesion
measuring 20mm x 15mm. The lesion was firm, indurated and tender on palpation.
Another case was a healthy 8 years old girl presented with a painful and non-healing ulcer
on the upper left posterior buccal mucosa for two months. The size was 7mm x 5mm with
rolled margin, indurated and tender to palpation. This ulcer was affecting her daily
activity, causing reduced oral intake, weight lost and sleep disturbance. Blood
investigation revealed increase in lymphocytes and eosinophils count. Both cases had no
history of trauma, lip biting or infections. No abnormalities detected from OPG. Surgical
excisional biopsies were done for both cases and histopathology result was suggestive of
Eosinophilic Ulcer. Upon review, the ulcers were completely healed after a month and no
recurrence noted. Conclusion: These cases are presented to highlight the clinical features
and management of EU. Early detection is essential to rule out other oral pathology and
to improve patient’s quality of life.

Presented at the 22 NIH Scientific Conference 2021, NIH Setia Alam on 21-23 September 2021.
nd
Dr Hans P Sathasivam
Institute for Medical Research
National Institutes of Health
Ministry of Health
Malaysia

Dr Aminah Marsom
Oral and Maxillofacial Surgery Department
Hospital Selayang
Ministry of Health
Malaysia

Dr Nurhidayah Muhd Noor
Department of Paediatric Dentistry
Hospital Melaka
Ministry of Health
Malaysia

Dr Mimi Syazleen Abdul Rahman
Department of Paediatric Dentistry
Hospital Sg Buloh
Ministry of Health
Malaysia

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